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KMID : 0372919940150010051
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Journal of Biomedical Engineering Research
1994 Volume.15 No. 1 p.51 ~ p.56
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Computer Model for Fibrinogen Adsorption on Polyurethane Surface
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Kim JW
Shin IS/Ryu GH/Lee KB/Han DK/Kim YH/Min BG
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Abstract
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Protein adsorption on the polyurethane surface was modelled by a modified random sequential ad- sorption(RSA) process. In this model, polyurethane surface was modelled as a mixed domain of hydrophobic and hydrophilic parts which was implemented by a 2 dimensional 150x150 lattice in the computer. Protein adsorption was simulated using a small box which represents a particle of the protein, and polyurethane lattice by considering their hydrophobic interaction. In order to validate the model, we performed fibrinogen adsorption on polyurethane surface Isotherms of the adsorbed protein were calculated and compared to the experimental data. The protein adsorption on the polyurethane surface could be well described using this computer model.
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